World Heart Care

Regenerative Cardiology & Stem Cell Therapies

Regenerative cardiology is redefining the possibility of repairing or replacing damaged heart tissue through biological restoration. Stem-cell–based therapies including induced pluripotent stem cells, mesenchymal stem cells, cardiac progenitors, and engineered tissues are being studied for their ability to regenerate myocardium, reverse fibrosis, stimulate angiogenesis, and improve cardiac function after injury. Gene-editing platforms like CRISPR and RNA-based technologies further enhance cell viability, integration, and therapeutic impact. Researchers are exploring cardiac patches, injectable biomaterials, and tissue-scaffold constructs designed to repair infarcted regions and restore contractility. Bioactive molecules and exosomes derived from stem cells provide additional regenerative pathways without requiring cell transplantation. Clinical trials continue to refine safety, dosing, and delivery methods to maximize therapeutic efficacy. Although full myocardial regeneration remains complex, progress in cellular engineering, immune modulation, and precision delivery systems is rapidly pushing the field toward clinical reality. The long-term vision is to transition from managing heart disease to reversing it, offering new hope to patients with previously irreversible cardiac damage.